Korean J Urol Oncol.
2022 Nov;20(4):273-277. 10.22465/kjuo.2022.20.4.273.
Rare Ewingoid Dedifferentiated Liposarcoma of the Spermatic Cord Causing Testicular Artery Compression: A Case Report
- Affiliations
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- 1Rowan University School of Osteopathic Medicine, Stratford, NJ, USA
- 2Department of Urology, Jefferson Health New Jersey, Stratford, NJ, USA
- 3Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA
- 4Lehigh University, Bethlehem, PA, USA
- 5Rocky Vista University College of Osteopathic Medicine, Ivins, UT, USA
- 6Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
- 7Department of General Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
- KMID: 2536656
- DOI: http://doi.org/10.22465/kjuo.2022.20.4.273
Abstract
- Liposarcomas of the spermatic cord are rare and often clinically and histologically misdiagnosed, leading to ineffective management and poor outcomes. We present a case of metastatic dedifferentiated liposarcoma of the spermatic cord, which recurred after excision of a misdiagnosed well-differentiated liposarcoma 3 years prior. Due to its size and high-grade metastasis, the tumor was unresectable, leading to treatment with systemic chemotherapy. Complications arose including partial compression of the testicular artery and urethral obstruction secondary to local mass effect. Tumor biopsy was characterized by a unique immunohistochemical profile which helped to explain the unique processes leading to mass effect, vascular and urethral compression, and bilateral scrotal swelling. The patient’s family history of malignancy and 22/22q trisomy identified in the tumor biopsy were also interesting contributors. In conclusion, accurate diagnosis of spermatic cord tumors is essential for effective treatment, and further data collection is required to improve management of advanced metastatic disease.
