Immune Netw.  2022 Oct;22(5):e39. 10.4110/in.2022.22.e39.

RNA Metabolism in T Lymphocytes

• Choi JO
• Ham JH
• Hwang SS

• KMID: 2536266
• DOI: http://doi.org/10.4110/in.2022.22.e39

Abstract

RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.

Keyword

T-lymphocytes; RNA; RNA metabolism; Immunity; Cellular