Korean J Parasitol.
2022 Oct;60(5):357-360. 10.3347/kjp.2022.60.5.357.
Excretory-Secretory Products of Trichomonas vaginalis Cause Apoptosis in Mouse Sperm in Vitro
- Affiliations
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- 1Deptartment of Obstetrics & Gynecology, College of Medicine, Hanyang University, Seoul 04763, Korea
- 2Laboratory of Reproductive Endocrinology, Deptartment. of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 04763, Korea
- 3Department of Environmental Biology & Medical Parasitology, College of Medicine, Hanyang University, Seoul 04763, Korea
- 4Department of Obstetrics & Gynecology, College of Medicine, Hanyang University, Guri 11923, Korea
- KMID: 2536003
- DOI: http://doi.org/10.3347/kjp.2022.60.5.357
Abstract
- Excretory-secretory products (ESP) of T. vaginalis have been shown to inhibit sperm motility, viability, and functional integrity, leading to a decreased fertilization rate in vitro. This study investigated whether T. vaginalis induce apoptosis and ultrastructural changes of sperm using flow cytometry and electron microscopy. Incubation of sperm with T. vaginalis ESP increased phosphatidylserine externalization and DNA fragmentation, and decreased mitochondrial membrane potential. Transmission electron microscopy of sperm incubated with ESP revealed abnormal features such as distorted heads, broken necks, and acrosomes exocytosis. This is the first report that demonstrates a direct impact of T. vaginalis ESP on sperm apoptosis and architecture in vitro.
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