Korean J Transplant.  2022 Nov;36(Supple 1):S138. 10.4285/ATW2022.F-2596.

Comparison of long-term outcomes in simultaneous pancreas-kidney transplant versus simultaneous deceased donor pancreas and living donor kidney transplant

• Kim JM
• Shin S
• Kim YH
• Kwon H
• Ko Y
• Jung JH
• Kwon HE
• Choi M
• Lee JJ

• KMID: 2535654
• DOI: http://doi.org/10.4285/ATW2022.F-2596

Abstract

Background
Because of the limited nature of organ transplants in most countries, many diabetic patients with end-stage renal disease might not have the chance to undergo simultaneous pancreas and kidney transplantation. To overcome this paucity of organs, simultaneous deceased donor pancreas and living donor kidney transplant (SPLK) can be implemented with certain ad-vantages over conventional simultaneous pancreas-kidney transplant (SPK).
Methods
A total of 195 patients who underwent SPK (n=149) or SPLK (n=46) were retrospectively analyzed. Their pre- and posttransplantation variables, development of de novo DSA, occurrence of biopsy-proven acute rejection (BPAR), and graft sur-vival rates were compared.
Results
There were no significant differences in the baseline characteristics between the SPK and SPLK groups except for the shorter cold ischemic time of kidney graft (331 vs. 93 minutes, P<0.001), shorter duration of diabetes (21.1 vs. 17.8 years, P=0.004), older age of pancreas graft-donors, and younger age of kidney graft-donors in the SPLK group. Ten years of fol-low-up data showed that the death-censored pancreas graft survival rate was significantly lower in the SPLK group. In addi-tion, the incidence of BPAR of the pancreas graft was significantly higher in the SPLK group (Fig. 1). There was no significant difference in the presence of de novo DSA and the incidence rates of kidney graft failure, kidney BPAR, and mortality between the two groups.
Conclusions
SPLK resulted in similar rates of early graft function and survival to those of SPK, albeit showing more incidences of acute rejection with regard to the pancreas graft.