Korean J Transplant.  2022 Nov;36(Supple 1):S91. 10.4285/ATW2022.F-2085.

Diagnosis of severe life-threatening decompensated liver cirrhotic complication via cytokines

• Ochirkhuree B
• Khangai A
• Soodoi C
• Duger 3 D

• KMID: 2535607
• DOI: http://doi.org/10.4285/ATW2022.F-2085

Abstract

Background
Mongolia is known to be the leading country in the world for liver cancer. The primary cause of liver cancer evidently reported were hepatic virus such as HCV, HBV and HDV. The high mortality of patient with liver cirrhosis is mostly due liver de-compensation related complication such as GI bleeding, hepatic failure, infection mostly due to spontaneous bacterial peritonitis (SBP). In this study we aimed to determine the SBP in early stages through examination of cytokines from peritoneal fluid.
Methods
Study was conducted among 58 hospitalized patients at the Gastroenterology Center of The FCHM between February to September 2020, who were diagnosed with liver cirrhosis and ascites. Ascites fluid was aspirated following the hospital proto-col via abdominal tab with a 16-inch needle guided by ultrasonography on the day 1 of hospitalize and examined for IL-4, IL-6 and INF-gamma.
Results
The average age for patients was 52.5 and 31 (53.4%) were males. The hepatic viral cirrhosis was 52 (89.6%). Of the total cases, 28 (48.2%) were CTP-B, and 30 (51.8%) were CTP-C and the mean model for end-stage liver disease score was 20.6. The SBP and non-SBP groups characteristics presented in table 1. Best cut-off value to determine SBP for IL-6 was 629.78 pg/mL with sensitivity and specificity both 100% in Mongolian patients.
Conclusions
In patient with liver cirrhosis, elevated IL-6 level (more than 630 pg/mL) in ascites can predict the SBP status as ear-ly as possible in limited secondary hospital and to start antibiotic treatment also as early as possible.