Korean J Transplant.  2022 Nov;36(Supple 1):S71. 10.4285/ATW2022.F-1880.

Effect of postoperative rapid amylase elevation on graft function after renal transplantation

Affiliations
  • 1Department of Vascular Surgery, The Catholic University of Korea Seoul St. Mary's Hospital, Seoul, Korea

Abstract

Background
In patients with renal failure, the excretion fraction of amylase is low, so serum amylase is usually increased, and it is often high even after kidney transplantation. Among them, it is not uncommon for amylase levels to increase to more than 1,000 without typical symptoms of pancreatitis, such as abdominal pain, nausea, or vomiting. There have been few studies investigating the direct relationship between rapid increased amylase level and delayed graft function (DGF).
Methods
This study was performed with 114 patients whose amylase level increased to more than 1,000 U/L at least once after renal transplantation between January 2010 and December 31, 2020 in our hospital. Group A was defined as patients whose amylase level increased to 1,000 or higher in 7 postoperative days, and group B was defined as patients whose amylase level in-creased after 7 postoperative days. The sex of each group, the number of transplants, the dialysis method before transplantation, the donor type, the rate of DGF, and mortality within 30 days after surgery were investigated.
Results
There were 95 patients in group A and 19 patients in group B, and the DGF rate of group A was significantly higher than that of group B (P<0.05). Other variants between the two groups including sex, number of transplants, dialysis method before transplantation, transplant type, and mortality within 30 days after surgery showed no significant difference.
Conclusions
The DGF rate of patients whose amylase level increased early after surgery was significantly high, so closer monitoring would be necessary for these patients after kidney transplantation.

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