Korean J Transplant.  2022 Nov;36(Supple 1):S323. 10.4285/ATW2022.F-4595.

Role of gender mismatch on outcomes of living donor kidney transplant recipient: a 5-year retrospective study

• Septiar D
• Hustrini NM
• Indriani A
• Septianto T
• Prabu OG
• Marbun MBH

• KMID: 2535550
• DOI: http://doi.org/10.4285/ATW2022.F-4595

Abstract

Background
Gender mismatch may affect graft survival. Female recipients of male kidneys have an inferior graft survival. This study aims to evaluate the role of gender mismatch in living donor kidney transplant (LDKT) recipient outcomes in Indonesia.
Methods
Retrospective cohort study was conducted to all donors and recipients of LDKT at Cipto Mangunkusumo Hospital from 2011 to 2016. Patient survival rate, all-cause and death censored graft survival were analyzed and associated with gender mismatch.
Results
A total 343 subjects were included. Most of the recipients were male (69.4%) and hypertensive (33.5%), with median age 48 years. Most of the donors were male (62.7%), with median age 30 years. We classified the donors and the recipients into 4 gender mismatches. The all-cause graft survivals was lower in male-to-female than male-to-male, female-to-male, and female-to-female (15 vs. 20, 36, and 36 months respectively), but not statistically significant (P=0.784). The acute rejection in female-to-male and male-to-female were higher than male-to-male and female-to-female (8.4% and 7.8% vs. 4.6% and 2%), but not statistically significant (P=0.439). The highest 5 year-graft survival was male-to-male (70,6%), with the lowest was female-to-female (66.7%), but not statistically significant (P=0.939). The death censored graft survival at 5 years was higher in male donor (80% in male-to-male and male-to-female) than in female donor group (74% in female-to-male and 76.5% in fe-male-to-female), but not statistically significant (P=0.674). The patient survival at 5 years was higher in female donor (75.3% in female-to-male and 70.6% in female-to-female) than in male donor group (65% in male-to-male and 69% in male-to-female), but not statistically significant (P=0.861).
Conclusions
Gender mismatch is not associated with acute rejection and 5 year-patient survival, all-cause and death censored graft survival. Male-to-female was the lowest in all-cause graft survival, but not statistically significant.