Nat Prod Sci.
2022 Sep;28(3):93-104. 10.20307/nps.2022.28.3.93.
Bioprospecting of Endophytic Fungi as Promising Anti-MRSA Agents
- Affiliations
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- 1Chemistry Section, School of Distance Education, Universiti Sains Malaysia, 11800 Penang, Malaysia
- 2School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia
- 3Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology, 78000 Alor Gajah, Melaka, Malaysia
- KMID: 2534098
- DOI: http://doi.org/10.20307/nps.2022.28.3.93
Abstract
- Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are needed to combat against bacterial resistance. Endophytic fungi are crucial reservoirs of novel bioactive metabolites. In particular, the secondary metabolites show promising therapeutic potential, notably, antibacterial. This review discussed the emerging potential of endophytic fungi as anti-MRSA agents. The ecological sources of endophytic fungi were discussed with the synthesis of bioactive metabolites. The mode of antibacterial actions was elucidated to give a better understanding of the mechanisms involved. This review may serve as an important reference for future discovery and developments of anti-MRSA agents from endophytic fungi.
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