Lab Med Qual Assur.  2022 Sep;44(3):136-142. 10.15263/jlmqa.2022.44.3.136.

Report of the Korean Association of External Quality Assessment Service on Accuracy-Based Creatinine Testing in Korea (2020–2021)

• Jeong TD
• Yun YM

• KMID: 2534077
• DOI: http://doi.org/10.15263/jlmqa.2022.44.3.136

Abstract

The accuracy-based creatinine (ABCr) proficiency testing (PT) program of the Korean Association of External Quality Assessment Service has become a mandatory program since 2020. This study analyzes the results of the ABCr PT program conducted from 2020 to 2021. The acceptability of the creatinine assay was based on the minimum requirement of the total error recommended by the National Kidney Disease Education Program, and the estimated glomerular filtration rate (eGFR) was based on the target value of ±30%. The creatinine test was performed for 1,623–1,664 participants, and the eGFR test was performed for 547–580 participants. The mean bias for the creatinine assay was approximately –2.9% to 6.55%. A sample with a low target creatinine concentration, such as less than 1.0 mg/dL, showed a positive bias trend, and a sample with a high concentration, such as greater than 2.0 mg/dL, showed a negative bias trend. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation showed a mean bias of approximately –4.7% to 3.7%, and the Modification of Diet in Renal Disease (MDRD) 4 variable isotope-dilution mass spectrometry (IDMS)-traceable equation showed a mean bias of approximately –3.2% to 5.3%. The acceptable rate of the creatinine assay for all participants varied from 69.2% to 95.0%, depending on the target value of creatinine concentration. The acceptable eGFR was 91.8% to 99.2% for the CKD-EPI and 96.9% to 99.8% for the MDRD 4 variable (IDMS-traceable).

Keyword

Accuracy; Creatinine; Estimated glomerular filtration rate; Proficiency testing