J Cancer Prev.
2022 Sep;27(3):157-169. 10.15430/JCP.2022.27.3.157.
Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders
- Affiliations
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- 1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul, Korea
- 2Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul, Korea
- 3Cancer Research Institute, Seoul National University, Seoul, Korea
- KMID: 2533965
- DOI: http://doi.org/10.15430/JCP.2022.27.3.157
Abstract
- Silent mating type information regulator 2 homolog 1 (SIRT1), an NAD + -dependent histone/protein deacetylase, has multifarious physiological roles in development, metabolic regulation, and stress response. Thus, its abnormal expression or malfunction is implicated in pathogenesis of various diseases. SIRT1 undergoes post-translational modifications, including phosphorylation, oxidation/reduction, carbonylation, nitrosylation, glycosylation, ubiquitination/deubiquitination, SUMOylation etc. which can modulate its catalytic activity, stability, subcellular localization, and also binding affinity for substrate proteins. This short review highlights the regulation of SIRT1 post-translational modifications and their pathophysiologic implications.
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