Diabetes Metab J.  2022 Sep;46(5):756-766. 10.4093/dmj.2021.0166.

Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population

• Lee MJ
• Khang AR
• Kang YH
• Yun MS
• Yi D

• KMID: 2533644
• DOI: http://doi.org/10.4093/dmj.2021.0166

Abstract

Background
The present study investigated the role of synergistic interaction between hyperuricemia and abdominal obesity as a risk factor for the components of metabolic syndrome.
Methods
We performed a cross-sectional study using the data of 16,094 individuals from the seventh Korean National Health and Nutrition Examination Survey (2016 to 2018). The adjusted odds ratios of metabolic syndrome and its components were analyzed by multivariate logistic regression analysis. The presence of synergistic interaction between hyperuricemia and abdominal obesity was evaluated by calculating the additive scales—the relative excess risk due to interaction, attributable proportion due to interaction, and synergy index (SI).
Results
There was a synergistic interaction between hyperuricemia and abdominal obesity in hypertriglyceridemia (men: SI, 1.39; 95% confidence interval [CI], 1.01 to 1.98; women: SI, 1.61; 95% CI, 1.02 to 2.69), and low high-density lipoprotein cholesterol (HDL-C) (men: SI, 2.03; 95% CI, 1.41 to 2.91; women: SI, 1.70; 95% CI, 1.05 to 2.95). There was no significant synergistic interaction between hyperuricemia and abdominal obesity for the risk of high blood pressure (men: SI, 1.22; 95% CI, 0.85 to 1.77; women: SI, 1.53; 95% CI, 0.79 to 2.97), and hyperglycemia (men: SI, 1.03; 95% CI, 0.72 to 1.47; women: SI, 1.39; 95% CI, 0.75 to 2.57).
Conclusion
Hyperuricemia and abdominal obesity synergistically increased the risk of hypertriglyceridemia and low HDL-C in both sexes.

Keyword

Hyperuricemia; Metabolic syndrome; Obesity; abdominal

Figure

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  Fig. 1 Flow diagram of the present study. KNHANES, Korea National Health and Nutrition Examination Survey; eGFR, estimated glomerular filtration rate.

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  Fig. 2 Synergistic interaction effect beween hyperuricemia and abodminal obesity on the metabolic syndrome components in men (A) and in women (B). BP, blood pressure; HDL-C, high-density lipoprotein cholesterol; AO, abdominal obesity; HU, hyperuricemia. aP<0.05 and indicated a synergistic interaction by synergy index.

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