Clin Psychopharmacol Neurosci.
2022 Aug;20(3):526-535. 10.9758/cpn.2022.20.3.526.
Haloperidol and Other Antipsychotics Exposure before Endometrial Cancer Diagnosis: A Population-based Case-control Study
- Affiliations
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- 1Aging Medicine Program, China Medical University, Taichung, Taiwan
- 2Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan
- 3Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan
- 4Department of Psychiatry and Mind-Body Interface Laboratory (MBI Lab.), China Medical University Hospital, China Medical University, Taichung, Taiwan
- 5Division of Clinical Toxicology, Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
- 6Division of Clinical Toxicology and Occupational Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- 7School of Medicine, National Defense Medical Center, Taipei, Taiwan
- 8Management Office for Health Data, China Medical University and Hospital, Taichung, Taiwan
- 9Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan
- 10Center for Translational Medicine, China Medical University and Hospital, Taichung, Taiwan
- 11Department of Social Work, Asia University, Taichung, Taiwan
- 12An-Nan Hospital, China Medical University, Tainan, Taiwan
- KMID: 2532817
- DOI: http://doi.org/10.9758/cpn.2022.20.3.526
Abstract
Objective
Endometrial cancer is the most common malignancy of the female genital tract worldwide, and the associated relationship between endometrial cancer formation and various antipsychotics need to be confirmed.
Methods
We conducted a case-control study by using data from Taiwan National Health Insurance Research Database to compare individual antipsychotic exposure between females with and without endometrial cancer. Among 14,079,089 females in the 12-year population-based national dataset, 9,502 females with endometrial cancer were identified. Their medical records of exposure to antipsychotics, including quetiapine, haloperidol, risperidone, olanzapine, amisulpride, clozapine, and aripiprazole, for up to 3 years before endometrial cancer diagnosis were reviewed. Daily dosage and cumulative exposure days were analyzed in the risky antipsychotic users. Additionally, the subsequent 5-year mortality rate of endometrial cancer among users of the risky antipsychotic were also analyzed.
Results
Among endometrial cancer patients, the proportion of those who have used haloperidol before being diagnosed with endometrial cancer is significantly higher than other antipsychotic users. The significant odds ratio (OR) and a 95% confidence interval of 1.75 (1.31−2.34) were noted. Furthermore, haloperidol users were associated with a significantly higher 5-year mortality rate after getting endometrial cancer than non-users.
Conclusion
There is a high correlation between the use of haloperidol and endometrial cancer formation. However, the underlying pathological biomechanisms require additional investigations.
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