J Korean Med Sci.  2022 Aug;37(33):e254. 10.3346/jkms.2022.37.e254.

Risk of Subsequent Events in Patients With Minor Ischemic Stroke or HighRisk Transient Ischemic Attack

• Lee KJ
• Shin DW
• Park HK
• Kim BJ
• Park JM
• Kang K
• Park TH
• Lee KB
• Hong KS
• Cho YJ
• Kim DE
• Ryu WS
• Lee BC
• Yu KH
• Oh MS
• Lee SJ
• Kim JG
• Lee J
• Cha JK
• Kim DH
• Kim JT
• Choi KH
• Choi JC
• Lesén E
• Hedberg J
• Tank A
• Fita EG
• Song JE
• Lee JS
• Lee J
• Bae HJ
• on behalf of the CRCS-K Investigators

• KMID: 2532629
• DOI: http://doi.org/10.3346/jkms.2022.37.e254

Abstract

This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.

Keyword

Minor Ischemic Stroke; Ischemic Attack; Transient; Event Outcome; Stroke Recurrence

Figure

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  Fig. 1 Adjusteda cumulative incidence of stroke or death (as composite and assessed individually) after minor AIS and TIA.AIS = acute ischemic stroke, TIA = transient ischemic attack.aDirect adjusted cumulative incidence by Cox proportional hazard regression analysis. Variables adjusted are age, gender, smoking, history of coronary heart disease, history of transient ischemic attack, history of stroke, history of hypertension, history of diabetes mellitus, history of dyslipidemia, history of atrial fibrillation and year of index date.

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