Ann Optom Contact Lens.
2022 Mar;21(1):8-14. 10.52725/aocl.2022.21.1.8.
Changes and Possible Role of Neuropeptides in Iatrogenic Dry Eye
- Affiliations
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- 1Department of Ophthalmology, Hangil Eye Hospital, Incheon, Korea
- 2Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
- 3Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
- 4Department of Ophthalmology, Catholic Kwandong University College of Medicine, Incheon, Korea
- KMID: 2532511
- DOI: http://doi.org/10.52725/aocl.2022.21.1.8
Abstract
- Recently, the role of the corneal nerve in the pathogenesis of dry eye disease (DED) has been highlighted. Considering that neuropeptides are known as important mediators between the nervous and immune systems, neurogenic inflammation induced and regulated by neuropeptides secreted from nerve terminals is expected to be involved in the pathogenesis of DED. And iatrogenic DED has been recently spotlighted as an important field with increasing interest in DED that occurs after ocular surgery or contact lens use. In this paper, recent studies on the role of neuropeptides in the pathogenesis of DED, in particular, the changes and possible roles of neuropeptides in iatrogenic DED were reviewed.
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