J Korean Soc Radiol.  2022 Jul;83(4):958-964. 10.3348/jksr.2021.0135.

Pulmonary Multinodular Epithelioid Hemangioendothelioma with Mixed Progression and Spontaneous Regression during a 7-Year Follow-Up: A Case Report and Review of Imaging Findings

• Yi GY
• Kim YK
• Kim KC
• Park HS

• KMID: 2532190
• DOI: http://doi.org/10.3348/jksr.2021.0135

Abstract

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of borderline or low-grade malignancy, and its prognosis is unpredictable. Herein, we describe the case of a 47-year-old asymptomatic female with a diagnosis of multinodular PEH. During a 7-year followup, the nodules with large size and high ¹⁸F-fluorodeoxyglucose uptake in the initial study showed progression with increasing sizes; however, most small nodules (size < 1 cm) demonstrated spontaneous regression with peripheral rim or nodular calcification. The patient underwent surgical resection for an enlarged nodule. Of note, it is unusual for an individual to have mixed progression and regression concomitantly, which may be helpful in predicting the prognosis.

Keyword

Hemangioendothelioma; Epithelioid; Computed Tomography; X-Ray; Positron Emission Tomography Computed Tomography