J Korean Med Sci.  2022 Jul;37(29):e239. 10.3346/jkms.2022.37.e239.

Monkeypox Vaccination in the Republic of Korea: Identifying the High-Risk Target Group

• Kwon SL
• Ban S
• Shin J
• Bae H
• Park H
• Kwon GY

• KMID: 2532090
• DOI: http://doi.org/10.3346/jkms.2022.37.e239

Abstract

In June 2022, the first monkeypox case was reported as imported into Korea. The general public asked whether they should get vaccinated against monkeypox because of the recent COVID-19 vaccination experience. As of the current monkeypox outbreak situation, a ring vaccination strategy for the high-risk group is more appropriate than the mass population vaccination with smallpox vaccines. Therefore, identifying the proper target group by available vaccines based on the risk and benefit analysis is a key issue of the vaccination program. In addition, the target group should be reviewed by the epidemiological situation of the jurisdiction along with the updated evidence of the monkeypox virus on transmission dynamics, severity, and fatality.

Keyword

Monkeypox; Vaccination; Smallpox Vaccine; Risk Assessment; Korea

Reference

1. Jang YR, Lee M, Shin H, Kim JW, Choi MM, Kim YM, et al. The first case of monkeypox in the Republic of Korea. J Korean Med Sci. 2022; 37(27):e224. PMID: 35818706.

2. World Health Organization. Vaccines and immunization for monkeypox: interim guidance. Accessed July 9, 2022. https://www.who.int/publications/i/item/who-mpx-immunization-2022.1 .

3. Kwon SL, Oh J. COVID-19 vaccination program in South Korea: a long journey toward a new normal. Health Policy Technol. 2022; 11(2):100601. PMID: 35127400.

4. Kucharski AJ, Eggo RM, Watson CH, Camacho A, Funk S, Edmunds WJ. Effectiveness of ring vaccination as control strategy for Ebola virus disease. Emerg Infect Dis. 2016; 22(1):105–108. PMID: 26691346.

5. Marriott KA, Parkinson CV, Morefield SI, Davenport R, Nichols R, Monath TP. Clonal vaccinia virus grown in cell culture fully protects monkeys from lethal monkeypox challenge. Vaccine. 2008; 26(4):581–588. PMID: 18077063.

6. Centers for Disease Control and Prevention. Monitoring people who have been exposed. Accessed July 12, 2022. https://www.cdc.gov/poxvirus/monkeypox/clinicians/monitoring.html .

7. United Kingdom Health Security Agency. Recommendations for the use of pre and post exposure vaccination during a monkeypox incident. Accessed July 12, 2022. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1083791/Recommendations-for-pre-and-post-exposure-vaccination-during-a-monkeypox-incident-17-june-2022.pdf .

8. United Kingdom Health Security Agency. Green book. Chapter 29: Smallpox and monkeypox. Accessed July 9, 2022. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1084396/Greenbook-chapter29-smallpox-and-monkeypox-21June22.pdf .

9. NBCNEWS. Monkeypox vaccines offered to gay and bisexual men in New York, Canada and U.K. Accessed July 9, 2022. https://www.nbcnews.com/health/health-news/monkeypox-vaccines-offered-gay-bisexual-men-rcna35035 .

10. United States Food and Drug Administration. ACAM2000 Package Insert. Accessed July 12, 2022. https://www.fda.gov/media/75792/download .

11. Korea Disease Control and Prevention Agency. Monkeypox response guidelines for local governments. Accessed July 9, 2022. https://kdca.go.kr/board/board.es?mid=a20507020000&bid=0019 .

12. Kim NH, Kang YM, Kim G, Choe PG, Song JS, Lee KH, et al. An open-label, single arm, phase III clinical study to evaluate the efficacy and safety of CJ smallpox vaccine in previously vaccinated healthy adults. Vaccine. 2013; 31(45):5239–5242. PMID: 24021303.