Diabetes Metab J.  2022 Jul;46(4):658-662. 10.4093/dmj.2021.0232.

Clinical Efficacy of Sodium-Glucose Cotransporter 2 Inhibitor and Glucagon-Like Peptide-1 Receptor Agonist Combination Therapy in Type 2 Diabetes Mellitus: Real-World Study

• Kim HS
• Yoon T
• Jung CH
• Park JY
• Lee WJ

• KMID: 2531969
• DOI: http://doi.org/10.4093/dmj.2021.0232

Abstract

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are novel anti-diabetic drugs whose glucose-lowering effect and cardiovascular and renal benefits were evidenced in clinical trials. We investigated the real-world efficacy and safety of the combination of SGLT2i and GLP-1RA in patients with type 2 diabetes mellitus in Korea. The medical records of 104 patients who maintained the combination for at least 1 year were retrospectively reviewed. The change in glycosylated hemoglobin (HbA1c) after 6 months and 1 year of treatment was evaluated. The mean age was 51 years, and 41% were female. The mean baseline HbA1c, body mass index, and duration of diabetes were 9.0%, 28.8 kg/m², and 11.7 years, respectively. Compared with baseline, the HbA1c decreased by 1.5% (95% confidence interval [CI], 1.27 to 1.74; P<0.001) after 6 months and by 1.4% (95% CI, 1.19 to 1.70; P<0.001) after 1 year. Over 1 year, the bodyweight change was −2.8 kg (95% CI, −4.21 to −1.47; P<0.001). The combination of SGLT2i and GLP-1RA is effective and tolerable in type 2 diabetes mellitus patients in real-world practice.

Keyword

Diabetes mellitus, type 2; Glucagon-like peptide-1 receptor; Sodium-glucose transporter 2 inhibitors

Figure

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  Fig. 1. Efficacy measures. (A) Changes in glycosylated hemoglobin (HbA1c), (B) changes in fasting plasma glucose (FPG), (C) changes in body weight after 6 months and 1 year of combination therapy. Data are presented as mean±standard deviation.aP<0.05, each compared with baseline.

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