Cancer Res Treat.  2022 Jul;54(3):873-881. 10.4143/crt.2021.400.

Daily Vigorous Intensity Physical Activity and Its Preventive Effect on Pancreatic Cancer

• Park SK
• Jung JY
• Oh CM
• Kim MH
• Ha E
• Kim Y
• Nam DJ
• Ryoo JH

• KMID: 2531333
• DOI: http://doi.org/10.4143/crt.2021.400

Abstract

Purpose
There has been accumulating evidence for the preventive effect of high physical activity on cancer. However, it is still unclear which level of physical activity is associated with the decreased risk of pancreatic cancer. The purpose of current study is to assess the association between the frequency of vigorous intensity physical activity and the risk of pancreatic cancer.
Materials and Methods
The nationwide retrospective cohort study was conducted using the National Health Information Database. Study participants were 220,357 Koreans who received health check-up in 2009. They were divided into four groups by the weekly frequency of vigorous intensity physical activity longer than 20 minutes (group 1, no vigorous intensity physical activity (reference); group 2, 1-3 days; group 3, 4-5 days and group 4, 6-7 days). Cox proportional hazard model was used to calculate the adjusted hazard ratios (HRs) and 95% confidence interval (CI) for incident pancreatic cancer (adjusted HRs [95% CI]) according to the weekly frequency of vigorous intensity physical activity.
Results
For 4.38 years’ follow-up on average, 377 cases of pancreatic cancer developed. Subjects without incident pancreatic cancer had more favorable metabolic condition and higher physical activity than subjects with incident pancreatic cancer. Adjusted HRs and 95% CI indicated that only group 4 was significantly associated with the decreased risk of pancreatic cancer (group 1, reference; group 2, 1.10 [0.86-1.40]; group 3, 0.75 [0.45-1.25] and group 4, 0.47 [0.25-0.89]).
Conclusion
In this nationwide representative cohort study, near daily vigorous intensity physical activity showed the preventive effect on pancreatic cancer.

Keyword

Pancreatic neoplasms; Prevention; Vigorous intensity physical activity

Figure

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  Fig. 1 Flow chart of enrolled study subjects.

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  Fig. 2 Parameters showing statistically significant difference between group without incident pancreatic cancer (control group) and group with incident pancreatic cancer (pancreatic cancer group). AST, aspartate aminotransferase; eGFR, estimated glomerular filtration rate; GGT, γ-glutamyltransferase; HDL, high-density lipoprotein; WC, waist circumference.

Reference

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