Korean J Transplant.  2022 Jun;36(2):154-158. 10.4285/kjt.22.0006.

Intractable right coronary artery spasm in the early postoperative period after heart transplantation: a case report

Affiliations
  • 1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
  • 2Department of Critical Care Medicine, Seoul National University Hospital, Seoul, Korea
  • 3Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Korea

Abstract

Coronary artery spasm after heart transplantation is a very rare complication. In one observational study and many anecdotal reports, most cases of coronary artery spasm occurred more than 1 year after surgery and had good outcomes. However, cases of intractable coronary artery spasm during the early postoperative period resulting in fatality are limited. This report presents a case of two cardiac arrests caused by coronary artery spasms within a short period of time after heart transplantation.

Keyword

Heart transplantation; Coronary vasospasm; Coronary angiography; Intravascular ultrasound; Myocardial revascularization; Case reports

Figure

  • Fig. 1 Electrocardiogram (ECG) during hospitalization. (A) Normal ECG after cardiac transplantation. (B) ECG after the first cardiac arrest, indicating inferior ST-segment elevation myocardial infarction (STEMI). (C) ECG after stent implantation to the right coronary artery with a stabilized ST segment. (D) ECG after the second cardiac arrest, indicating inferior STEMI.

  • Fig. 2 Coronary angiography (CAG) and intravascular ultrasound after cardiac arrest. (A) CAG of the right coronary artery (RCA) before stent implantation revealed multiple vasospasm. (B) Intravascular ultrasound of the proximal RCA found a large plaque burden (up to 75.5%). (C) A drug-eluting stent was implanted into the proximal RCA. (D) CAG of the RCA after the second cardiac arrest revealed a severe diffuse coronary spasm, except in the area of the stent-implanted proximal lesion.


Reference

1. Boffa GM, Livi U, Grassi G, Casarotto D, Isabella G, Cardaioli P, et al. 2000; Angiographic presentation of coronary artery spasm in heart transplant recipients. Int J Cardiol. 73:67–74. DOI: 10.1016/S0167-5273(99)00225-9. PMID: 10748313.
2. Pagnoni M, Regamey J, Adjedj J, Rogati G, Muller O, Tozzi P. 2019; Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon. BMC Cardiovasc Disord. 19:305. DOI: 10.1186/s12872-019-01280-8. PMID: 31856732. PMCID: PMC6924038.
3. Pistono M, Brentana L, Gnemmi M, Imparato A, Temporelli PL, Zingarelli E, et al. 2009; Early right coronary vasospasm presenting with malignant arrhythmias in a heart transplantation recipient without allograft vasculopathy. Int J Cardiol. 131:e120–3. DOI: 10.1016/j.ijcard.2007.07.078. PMID: 17950482.
4. Sheu R, Berfield K, Jones S, Pal J, Mackensen GB. 2017; Intraoperative acute multivessel coronary vasospasm in cardiac allograft: a case report. A A Case Rep. 9:328–31. DOI: 10.1213/XAA.0000000000000608. PMID: 28727596.
5. Hung MJ, Hu P, Hung MY. 2014; Coronary artery spasm: review and update. Int J Med Sci. 11:1161–71. DOI: 10.7150/ijms.9623. PMID: 25249785. PMCID: PMC4166862.
6. Takagi Y, Takahashi J, Yasuda S, Miyata S, Tsunoda R, Ogata Y, et al. 2013; Prognostic stratification of patients with vasospastic angina: a comprehensive clinical risk score developed by the Japanese Coronary Spasm Association. J Am Coll Cardiol. 62:1144–53. DOI: 10.1016/j.jacc.2013.07.018. PMID: 23916938.
7. Cho S, Kang TS. 2018; Multi-vessel intractable coronary spasm development in a patient with aborted sudden cardiac death: a case study with intravascular ultrasound findings. Yeungnam Univ J Med. 35:121–6. DOI: 10.12701/yujm.2018.35.1.121. PMID: 31620582. PMCID: PMC6784666.
8. Jiang M, Kaplan RM, Peigh G, Cheema B, Sawicki KT, Pfenniger A, et al. 2020; Vasospastic arrest: a heart-stopping case of prinzmetal angina. JACC Case Rep. 2:611–4. DOI: 10.1016/j.jaccas.2020.01.007. PMID: 32432226. PMCID: PMC7236804.
9. Tanabe Y, Itoh E, Suzuki K, Ito M, Hosaka Y, Nakagawa I, et al. 2002; Limited role of coronary angioplasty and stenting in coronary spastic angina with organic stenosis. J Am Coll Cardiol. 39:1120–6. DOI: 10.1016/S0735-1097(02)01746-1. PMID: 11923034.
10. Copeland H, Hayanga JW, Neyrinck A, MacDonald P, Dellgren G, Bertolotti A, et al. 2020; Donor heart and lung procurement: a consensus statement. J Heart Lung Transplant. 39:501–17. DOI: 10.1016/j.healun.2020.03.020. PMID: 32503726.
Full Text Links
  • KJT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr