Nat Prod Sci.
2022 Jun;28(2):53-57. 10.20307/nps.2022.28.2.53.
A New Dimeric Lignan from the Stems of Willughbeia edulis
- Affiliations
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- 1Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam
- 2Vietnam National University, Ho Chi Minh City, Vietnam
- 3Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam
- KMID: 2530931
- DOI: http://doi.org/10.20307/nps.2022.28.2.53
Abstract
- As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acidcatalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show α-glucosidase inhibitory activity with an IC 50 value > 250 μM.
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