Korean J Fam Pract.  2022 Jun;12(3):137-143. 10.21215/kjfp.2022.12.3.137.

Association between Estimated Glomerular Filtration Rate and Hand-Grip Strength in South Korean 60 Years of Age or Older: 2016–2018 Korea National Health and Nutrition Examination Survey

Affiliations
  • 1Department of Family Medicine, Korea University Guro Hospital, Seoul, Korea

Abstract

Background
This study aimed to investigate the relationship between estimated glomerular filtration rate (eGFR [mL/min per 1.73 m 2 ]) measured using modification of diet in renal disease equation and hand-grip strength (HGS [kg]) in patients ≥60 years of age in South Korea.
Methods
Our analysis involved 5,165 individuals from the Korea National Health and Nutrition Examination Survey 2016 to 2018. The participants were aged ≥60 years, and their HGS and serum creatinine levels were measured. Participants diagnosed with cancer were excluded. The participants were categorized according to their eGFR: subgroup 1, eGFR≥90; subgroup 2, 60≤eGFR<90; subgroup 3, 45≤eGFR<60; and subgroup 4, eGFR<45. The participants were also categorized into the stronger and weaker HGS groups based on their average HGS. Data were analyzed using Pearson’s chisquared test and logistic regression analysis.
Results
After correcting all confounding variable, decreased kidney function was associated with increasing odd ratios for weak HGS in female participant (model 3, P for trend=0.043). Additionally, subgroup 4 (eGFR <45 mL/min per 1.73 m 2 ) showed that the odd ratio for weak HSG was 4.496 (95% CI, 1.422–14.211; P for trend=0.043), when compared to subgroup 1 (eGFR ≥90 mL/min per 1.73 m 2 ) and the stronger HGS group in female participants; however, it was not statistically significant in male participants.
Conclusion
Among the elderly (≥60 years) in South Korean, female patients with an eGFR <45 mL/min per 1.73 m 2 exhibit reduced HGS. Future research should focus on clarifying the relationship between eGFR and HGS.

Keyword

Aged; Estimated Glomerular Filtration Rate; Hand-Grip Strength; Sarcopenia
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