Psychiatry Investig.  2022 Jun;19(6):443-450. 10.30773/pi.2022.0011.

State and Trait Anxiety Related Gamma Oscillations in Patients With Anxiety Within the Research Domain Criteria Framework

• Kim KM
• Bong SH
• Byeon J
• Kim JW

• KMID: 2530619
• DOI: http://doi.org/10.30773/pi.2022.0011

Abstract

Objective
Diagnosis of anxiety has relied primarily on self-report. This study aimed to investigate the neural correlates of anxiety with quantitative electroencephalography (qEEG) focusing on the state and trait anxiety defined according to the Research Domain Criteria framework existing across the differential diagnosis, rather than focusing on the diagnosis.
Methods
A total of 41 participants who visited a psychiatric clinic underwent resting state EEG and completed the State-Trait Anxiety Inventory. The absolute power of six frequency bands were analyzed: delta (1–4 Hz), theta (4–8 Hz), alpha (8–10 Hz), fast alpha (10–13.5 Hz), beta (13.5–30 Hz), and gamma (30–80 Hz).
Results
State anxiety scores were significantly negatively correlated with absolute gamma power in frontal (Fz, r=-0.484) and central (Cz, r=-0.523) regions, while trait anxiety scores were significantly negatively correlated with absolute gamma power in frontal (Fz, r= -0.523), central (Cz, r=-0.568), parietal (P7, r=-0.500; P8, r=-0.541), and occipital (O1, r=-0.510; O2, r=-0.480) regions.
Conclusion
The present study identified the significantly negative correlations between the anxiety level and gamma band power in fronto-central and posterior regions assessed at resting status. Further studies to confirm our findings and identify the neural correlates of anxiety are needed.

Keyword

Anxiety; Trait; State; Quantitative electroencephalography; Resting state