Korean J Radiol.
2022 Jun;23(6):581-597. 10.3348/kjr.2021.0815.
Differential Diagnosis of Thick Myocardium according to Histologic Features Revealed by Multiparametric Cardiac Magnetic Resonance Imaging
- Affiliations
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- 1Department of Radiology, Chung-Ang University Hospital, Seoul, Korea
- 2Department of Radiology, Korea University Ansan Hospital, Ansan, Korea
- 3Department of Radiology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
- 4Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 5Department of Radiology and Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- 6Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- KMID: 2530354
- DOI: http://doi.org/10.3348/kjr.2021.0815
Abstract
- Left ventricular (LV) wall thickening, or LV hypertrophy (LVH), is common and occurs in diverse conditions including hypertrophic cardiomyopathy (HCM), hypertensive heart disease, aortic valve stenosis, lysosomal storage disorders, cardiac amyloidosis, mitochondrial cardiomyopathy, sarcoidosis and athlete’s heart. Cardiac magnetic resonance (CMR) imaging provides various tissue contrasts and characteristics that reflect histological changes in the myocardium, such as cellular hypertrophy, cardiomyocyte disarray, interstitial fibrosis, extracellular accumulation of insoluble proteins, intracellular accumulation of fat, and intracellular vacuolar changes. Therefore, CMR imaging may be beneficial in establishing a differential diagnosis of LVH. Although various diseases share LV wall thickening as a common feature, the histologic changes that underscore each disease are distinct. This review focuses on CMR multiparametric myocardial analysis, which may provide clues for the differentiation of thickened myocardium based on the histologic features of HCM and its phenocopies.
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