Korean Circ J.  2022 May;52(5):398-400. 10.4070/kcj.2021.0408.

Multiple Micro-Neo-Vessels Detected by Optical Coherence Tomography (OCT) May Predict a Progression of Cardiac Allograft Vasculopathy in Posttransplant Recipients

• Suzuki T
• Kato TS
• Nishikura T
• Shibata K
• Tanno K
• Wakabayashi K

• KMID: 2529872
• DOI: http://doi.org/10.4070/kcj.2021.0408

Figure

• 

  Figure 1 Hematoxylin-Eosin staining and the immunostaining of C4d and CD68. The histology at the year X-1.5 showed mild cellular and antibody-mediated rejection (A, ISHLT grade 1R and pAMR 2), which were resolved in the specimen at the year X (B, ISHLT grade 0, pAMR 0).ISHLT = International Society for Heart and Lung Transplantation; pAMR = pathologic diagnosis of antibody-mediated rejection.

• 

  Figure 2 The angiograms of left coronary artery (A), and the associated OCT findings at the proximal (green arrow) and distal (yellow arrow) segments of a left anterior descending artery (B and C, respectively) obtained at the year X-1.5 (left) and the year X (right). The multiple micro-neovessels in the proximal segment seen at the year X-1.5 (B, green arrows) regressed without coronary narrowing. The bright spot at the distal segment progressed to the layered fibrotic plaque and the localized fibrotic plaque increased in thickness (C, yellow arrow and star marks, respectively), reflecting the stability of the coronary plaque.

Reference

1. Clemmensen TS, Holm NR, Eiskjær H, et al. Layered fibrotic plaques are the predominant component in cardiac allograft vasculopathy: systematic findings and risk stratification by OCT. JACC Cardiovasc Imaging. 2017; 10:773–784. PMID: 28330670.

2. Hendon CP, Lye TH, Yao X, Gan Y, Marboe CC. Optical coherence tomography imaging of cardiac substrates. Quant Imaging Med Surg. 2019; 9:882–904. PMID: 31281782.