Gut Liver.  2022 May;16(3):384-395. 10.5009/gnl210141.

Quality of Life in Newly Diagnosed Moderate-to-Severe Ulcerative Colitis: Changes in the MOSAIK Cohort Over 1 Year

Affiliations
  • 1Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
  • 2Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
  • 3Department of Internal Medicine, Chosun University Hospital, Gwangju, Korea.
  • 4Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.
  • 5Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea.
  • 6Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • 7Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 8Department of Internal Medicine, Samsung Medical Center, Seoul, Korea.
  • 9Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
  • 10Department of Internal Medicine, Wonju Severance Christian Hospital, Wonju, Korea.
  • 11Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
  • 12Clinical Research Science Team, Medical Affairs, Janssen Korea Ltd., Seoul, Korea.

Abstract

Background/Aims
Improving quality of life has been gaining importance in ulcerative colitis (UC) management. The aim of this study was to investigate changes in health-related quality of life (HRQL) and related factors in patients with moderate-to-severe UC.
Methods
A multicenter, hospital-based, prospective study was performed using a Moderateto-Severe Ulcerative Colitis Cohort in Korea (the MOSAIK). Changes in HRQL, evaluated using the 12-Item Short Form Health Survey (SF-12) and Inflammatory Bowel Disease Questionnaire (IBDQ), were analyzed at the time of diagnosis and 1 year later.
Results
In a sample of 276 patients, the mean age was 38.4 years, and the majority of patients were male (59.8%). HRQL tended to increase in both the IBDQ and SF-12 1 year after diagnosis. A higher partial Mayo score was significantly related to poorer HRQL on the IBDQ and SF-12 in a linear mixed model (p<0.01). Inflammatory markers such as C-reactive protein (CRP) or erythrocyte sedimentation rate also showed a negative correlation on HRQL (p<0.05). Patients whose IBDQ score improved by 16 or more (71.2%) in 1 year were younger, tended to be nonsmokers, and had a lower partial Mayo score and CRP than those whose IBDQ score did not. There was no significant association between HRQL and disease extent, treatments at diagnosis, or the highest treatment step during the 1-year period.
Conclusions
Optimally controlled disease status improves HRQL in patients with moderate-tosevere UC. The partial Mayo score and inflammatory markers may be potential indicators reflecting the influence of UC on patient`s daily lives.

Keyword

Colitis; ulcerative; Quality of life; Treatment outcome; Cohort studies
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