J Korean Neurosurg Soc.  2022 May;65(3):354-360. 10.3340/jkns.2021.0308.

Pediatric Severe Traumatic Brain Injury : Updated Management

Affiliations
  • 1Department of Critical Care Medicine, Seoul National University Hospital, Seoul, Korea

Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability in children. Survivors of severe TBI are more susceptible to functional deficits, resulting in disability, poor quality of life, cognitive decline, and mental health problems. Despite this, little is known about the pathophysiology of TBI in children and how to manage it most effectively. Internationally, efforts are being made to expand knowledge of pathophysiology and develop practical clinical treatment recommendations to improve outcomes. Here we discuss recently updated evidence and management of severe pediatric TBI.

Keyword

Traumatic brain injury; Pediatrics; Critical care; Intracranial pressure; Practice guideline

Figure

  • Fig. 1. The evidence- and consensus-based algorithm of the management for the severe TBI in pediatric patients. The algorithm includes several components, such as baseline care (black), an ICP pathway (yellow), a herniation pathway (green), a CPP pathway (orange), and a PbrO2 pathway (purple). Solid lines identify the ICP and CPP pathways, reflecting their primary role. If baseline care is insufficient to control ICP, first-tier interventions progressing down the ICP pathway. The blue box indicates the need for second-tier therapy. TBI : traumatic brain injury, GCS : Glasgow coma scale, CT : computed tomography, ICP : intracranial pressure, PbrO2 : brain tissue partial pressure of oxygen, CPP : cerebral perfusion pressure


Reference

References

1. Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, et al. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (cool kids): a phase 3, randomised controlled trial. Lancet Neurol. 12:546–553. 2013.
Article
2. Alberico AM, Ward JD, Choi SC, Marmarou A, Young HF. Outcome after severe head injury. Relationship to mass lesions, diffuse injury, and ICP course in pediatric and adult patients. J Neurosurg. 67:648–656. 1987.
3. Alkhoury F, Kyriakides TC. Intracranial pressure monitoring in children with severe traumatic brain injury: national trauma data bank-based review of outcomes. JAMA Surg. 149:544–548. 2014.
Article
4. Araki T, Yokota H, Morita A. Pediatric traumatic brain injury: characteristic features, diagnosis, and management. Neurol Med Chir (Tokyo). 57:82–93. 2017.
Article
5. Beca J, McSharry B, Erickson S, Yung M, Schibler A, Slater A, et al. Hypothermia for traumatic brain injury in children-a phase II randomized controlled trial. Crit Care Med. 43:1458–1466. 2015.
Article
6. Bennett TD, Riva-Cambrin J, Keenan HT, Korgenski EK, Bratton SL. Variation in intracranial pressure monitoring and outcomes in pediatric traumatic brain injury. Arch Pediatr Adolesc Med. 166:641–647. 2012.
Article
7. Biswas AK, Bruce DA, Sklar FH, Bokovoy JL, Sommerauer JF. Treatment of acute traumatic brain injury in children with moderate hypothermia improves intracranial hypertension. Crit Care Med. 30:2742–2751. 2002.
Article
8. Carney N, Totten AM, O’Reilly C, Ullman JS, Hawryluk GW, Bell MJ, et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery. 80:6–15. 2017.
Article
9. Chambers IR, Treadwell L, Mendelow AD. Determination of threshold levels of cerebral perfusion pressure and intracranial pressure in severe head injury by using receiver-operating characteristic curves: an observational study in 291 patients. J Neurosurg. 94:412–416. 2001.
Article
10. Coronado VG, Xu L, Basavaraju SV, McGuire LC, Wald MM, Faul MD, et al. Surveillance for traumatic brain injury-related deaths--United States, 1997-2007. MMWR Surveill Summ. 60:1–32. 2011.
11. Cruz J, Nakayama P, Imamura JH, Rosenfeld KG, De Souza HS, Giorgetti GV. Cerebral extraction of oxygen and intracranial hypertension in severe, acute, pediatric brain trauma: preliminary novel management strategies. Neurosurgery. 50:774–779. 2002.
Article
12. Dewan MC, Mummareddy N, Wellons JC 3rd, Bonfield CM. Epidemiology of global pediatric traumatic brain injury: qualitative review. World Neurosurg. 91:497–509. 2016.
Article
13. Downard C, Hulka F, Mullins RJ, Piatt J, Chesnut R, Quint P, et al. Relationship of cerebral perfusion pressure and survival in pediatric braininjured patients. J Trauma. 49:654–658. 2000.
Article
14. Fisher B, Thomas D, Peterson B. Hypertonic saline lowers raised intracranial pressure in children after head trauma. J Neurosurg Anesthesiol. 4:4–10. 1992.
Article
15. Gardner MT, O’Meara AMI, Miller Ferguson N. Pediatric traumatic brain injury: an update on management. Current Pediatrics Reports. 5:213–219. 2017.
Article
16. Gelineau-Morel RN, Zinkus TP, Le Pichon JB. Pediatric head trauma: a review and update. Pediatr Rev. 40:468–481. 2019.
Article
17. Haarbauer-Krupa JK, Glang A, Kurowski B, Breiding MJ. Report to congress : the management of traumatic brain injury in children. Available at : https://www.cdc.gov/traumaticbraininjury/pubs/congress-childrentbi.html.
18. Honeybul S, Ho KM, Gillett GR. Long-term outcome following decompressive craniectomy: an inconvenient truth? Curr Opin Crit Care. 24:97–104. 2018.
19. Hutchison JS, Frndova H, Lo TY, Guerguerian AM. Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia pediatric head injury trial. Dev Neurosci. 32:406–412. 2010.
Article
20. Kapapa T, König K, Pfister U, Sasse M, Woischneck D, Heissler H, et al. Head trauma in children, part 2: course and discharge with outcome. J Child Neurol. 25:274–283. 2010.
Article
21. Kochanek PM, Clark RS, Ruppel RA, Adelson PD, Bell MJ, Whalen MJ, et al. Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: lessons learned from the bedside. Pediatr Crit Care Med. 1:4–19. 2000.
Article
22. Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, et al. Management of pediatric severe traumatic brain injury: 2019 consensus and guidelines-based algorithm for first and second tier therapies. Pediatr Crit Care Med. 20:269–279. 2019.
23. Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, et al. Guidelines for the management of pediatric severe traumatic brain injury, third edition: update of the brain trauma foundation guidelines, executive summary. Neurosurgery. 84:1169–1178. 2019.
Article
24. Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, et al. Guidelines for the management of pediatric severe traumatic brain injury, third edition: update of the brain trauma foundation guidelines. Pediatr Crit Care Med. 20:S1–S82. 2019.
25. Lewis PM, Czosnyka M, Carter BG, Rosenfeld JV, Paul E, Singhal N, et al. Cerebrovascular pressure reactivity in children with traumatic brain injury. Pediatr Crit Care Med. 16:739–749. 2015.
Article
26. Nacoti M, Fazzi F, Biroli F, Zangari R, Barbui T, Kochanek PM, et al. Addressing key clinical care and clinical research needs in severe pediatric traumatic brain injury: perspectives from a focused international conference. Front Pediatr. 8:594425. 2021.
27. Natale JE, Joseph JG, Helfaer MA, Shaffner DH. Early hyperthermia after traumatic brain injury in children: risk factors, influence on length of stay, and effect on short-term neurologic status. Crit Care Med. 28:2608–2615. 2000.
Article
28. Shein SL, Ferguson NM, Kochanek PM, Bayir H, Clark RS, Fink EL, et al. Effectiveness of pharmacological therapies for intracranial hypertension in children with severe traumatic brain injury--results from an automated data collection system time-synched to drug administration. Pediatr Crit Care Med. 17:236–245. 2016.
Article
29. Shi J, Xiang H, Wheeler K, Smith GA, Stallones L, Groner J, et al. Costs, mortality likelihood and outcomes of hospitalized US children with traumatic brain injuries. Brain Inj. 23:602–611. 2009.
Article
30. Tremlett W, Kanthimathinathan HK. Cerebral autoregulation monitoring in children with mild traumatic brain injury. Pediatr Crit Care Med. 20:694–695. 2019.
31. Wahlström MR, Olivecrona M, Koskinen LO, Rydenhag B, Naredi S. Severe traumatic brain injury in pediatric patients: treatment and outcome using an intracranial pressure targeted therapy--the lund concept. Intensive Care Med. 31:832–839. 2005.
Article
32. Wang CF, Zhao CC, Jiang G, Gu X, Feng JF, Jiang JY. The role of posttraumatic hypothermia in preventing dendrite degeneration and spine loss after severe traumatic brain injury. Sci Rep. 6:37063. 2016.
Article
33. Yue JK, Rick JW, Deng H, Feldman MJ, Winkler EA. Efficacy of decompressive craniectomy in the management of intracranial pressure in severe traumatic brain injury. J Neurosurg Sci. 425–440. 2019.
Article
Full Text Links
  • JKNS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr