Tuberc Respir Dis.  1969 Mar;16(1):17-23. 10.4046/trd.1969.16.1.17.

Study on the Primary Drug Resistance in Korea During 1962-1967

• KMID: 2529159
• DOI: http://doi.org/10.4046/trd.1969.16.1.17

Abstract

The Primary Drug Resistance for isoniazid. PAS and Streptomycin among 1. 110 cases of pulmonary tuberculosis were without previous chemotherapy observed for six years. from 1962 to 1967. The study was made according to the sensitivity test method for M. tuberculosis of the British Medical Research Council, and the concentration of drugs were; isoniazid 0.2, 1. 5 mcg/ ml, PAS 1. 5. 10 mcg/ ml. and Streptomycin 10. 20. 200 mcg/ ml before inspissation The resistant strains obtained from this study were obsered again on its proportion of the resistant bacilli. Summary 1. The prevalence of primary drug resistance to Isoniazid. PAS and Streptomycin. either single or in combination. was 23. 5%. and which is higher than those of foreign countries. 2. Tendency of primary drug resistance in Korea was increased, during 1962-1964 it was 19. 2%. and 27. 5% during 1965-1967. (Table 1) 3. Incidence of primary resistant strain by during, lsoniazid was the highest as shown in table 2 from 7.7% in 1962 to 25.4% in 1967. Otherwise. incidence of primary resistance of PAS and Streptomycin remained almost same level. (According to resistant by drugs) . 4. Isoniazid single-resistant case was the highest and increased annually. 5. Proportion of the drug-resistance tubercle bacilli were observed; Complete resistance to INH and S.M. were increa sed annually, further more it was observed that few of them were complete resistant to 5 mrg ml / of INH.