Tuberc Respir Dis.  1984 Dec;31(4):165-170. 10.4046/trd.1984.31.4.165.

Crossresistance between Tuberactinomycin-N, Capreomycin and Kanamycin of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis

• KMID: 2528759
• DOI: http://doi.org/10.4046/trd.1984.31.4.165

Abstract

Three hundred and thirty three strains of M. tuberculosis isolated from patients with pulmonary tuberculosis who had no history of chemotherapy were completely inhibited at 50 mcg/ ml of Tuberactinomycin-N and 98% or more strains, at 25 mcg/ ml in LöwensteinJensen medium. Of 183 strains from patients treated with KM for more than 6 months, 63 strains(34.4%) were resistant at 100 mcg/ ml of KM. Of those KM resistant strains, 53(84.1 %) were resistant to CPM while only 3 strains(4.8% ) were resistant to TUM-N. The drug susceptibility pattern of 2,759 strains from patients whose chemotherapy history were not known indicated considerable cross-resistance between TUM-N and CPM and one-way cross-resistance from KM to CPM, meanwhile cross-resistance from TUM-N or CPM to 'KM were not significant.