Tuberc Respir Dis.  1985 Mar;32(1):46-53. 10.4046/trd.1985.32.1.46.

Angiotensin Converting Enzyme in Human Adult Respiratory Distress Syndrome

• KMID: 2528756
• DOI: http://doi.org/10.4046/trd.1985.32.1.46

Abstract

Angiotensin converting enzyme (ACE) is almost entirely derived from pulmonary endothelium and the activity of ACE could be used as an index of the pulmonary endothelial damage. We measured the ratio of arterial oxygen partial pressure to inspired oxygen fraction(PaO₂/FiO₂) and serum ACE levels in 16 patients with adult respiratory distress syndrome (ARDS) daily from day 1 to 7 on ventilator to study correlation between ACE and PaO₂/FiO₂ and the predictive value of ACE in 7 patients with sepsis and 7 patients with high pressure edema and to study value of ACE in the differential diagnosis between sepsis with or without ARDS and between ARDS and high pressure pulmonary edema. Our data is shown: Serum ACE and PaO₂/FiO₂ were not correlated(r = - 0.04, P> 0.1 ). The result of this study suggests that serum ACE level may be useful in differential diagnosis between sepsis with or without ARDS and between ARDS and high pressure pulmonary edema but have no prognostic value in predicting survival or death of a patient with ARDS.