Tuberc Respir Dis.  1986 Mar;33(1):43-50. 10.4046/trd.1986.33.1.43.

Effect of Smoking on Secretory IgA in Bronchoalveolar Lavage Fluid

• KMID: 2528713
• DOI: http://doi.org/10.4046/trd.1986.33.1.43

Abstract

Synthesis of S-IgA in bronchial tree is dependent on the epithelial cell function, which could be influenced by smoking. To evaluate the effect of smoking on bronchial epithelium and the value of S-IgA to differentiate malignancy from benign lung diseases, S-IgA was measured in the bronoalveolar lavage fluid of 34 patients with lung cancer and pulmonary tuberculosis. The results were as follows: 1) S-IgA concentration of BAL fluid is 2.61± 1.93 flg/m1 in smokers compared with 5.26 ±3.66 μg/ml in nonsmokers(p<0.025). 2) There was no difference of S-IgA concentration in BAL fluid not only between cancer-smoker group and tuberculosis-smoker group but also between cancer-nonsmoker group and tuberculosis-nonsmoker group. 3) Serum S-IgA concentration of smokers is not different from that of nonsmoker. 4) The ratio of S-IgA to albumin in BAL fluid to S-IgA to albumin in serum is above 1.0 in all cases and that smokers is not different from that of nonsmokers. In conclusion, the smoking causes S-IgA synthesis in bronchial tree to diminish and S-IgA measurement in serum and BAL fluid have no diagnostic value to differentiate malignant disease from Benign lung disease.