Tuberc Respir Dis.  1989 Sep;36(3):233-237. 10.4046/trd.1989.36.3.233.

Site of Bronchodilatation with Inhaled Fenoterol and Ipratropium Bromide in Bronchial Asthma

• KMID: 2528545
• DOI: http://doi.org/10.4046/trd.1989.36.3.233

Abstract

To assess site of action of bronchodilatation with a beta adrenergic agonist, fenoterol, and an anticholinergic bronchodilator, ipratropium bromide, we measured the density dependence of maximal expiratory flow rate in 37 asthmatics There were no significant changes in Δ V max 50 with either agent. However, there were significant inverse correlations between the prebronchodilator Δ V max 50 and the change in ΔV max 50 after the administration of fenoterol or ipratropium. These results suggest that sites of bronchodilatation in asthmatics are not different between fenoterol and ipratropium, and those are related to the prebronchodilator site of obstruction.