Tuberc Respir Dis.  1990 Mar;37(1):29-35. 10.4046/trd.1990.37.1.29.

Clinical Analysis on the Brain Metastases of Bronchogenic Carcinoma

• KMID: 2528508
• DOI: http://doi.org/10.4046/trd.1990.37.1.29

Abstract

In a series of 302 patients with bronchogenic carcinoma who were seen at the Chonnam University Hospital, in the Kwangju, Korea from March 1983 to August 1988, the pattern and radiation efficacy of brain metastases were retrospectively analyzed in the 32 patients showing intracranial involvement on the brain CT scan. The mean age of patients was 57.2 years and nearly all of them were beyond 40 years old. The ma Je to female ratio was 5.4:1. Overall frequency of brain metastases from bronchogenic carcinoma was 10.6%. These metastases were seen in 18.8% of patients with small cell carcinoma, 16% with adenocarcinoma, and 8.3% with squamous cell carcinoma. The most frequent symptom in 32 patients with brain metastases was headache and 59% of them showed brain metastases at the time of diagnosis of lung cancer. The metastatic pattern on brain CT scan revealed mainly single, round rather than multiple nodules, in association with iso-and hyperdense lesions. The frontal and parietal lobes were commonly involved. The median survival time of non-small-cell lung cancer with brain metastases tended to be longer than that of small cell lung cancer group And particularly in the non-small cell lung cancer group who received palliative cranial irradiation, the median survival time was significantly prolonged as compared to non-irradiation patients