J Biomed Transl Res.
2021 Sep;22(3):141-147. 10.12729/jbtr.2021.22.3.141.
Congestive heart failure caused by myxomatous mitral valve degeneration in a Siberian tiger
- Affiliations
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- 1Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
- 2Cheongju Zoo, Cheongju 28311, Korea
- 3Laboratory of Veterinary Surgery and Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
- KMID: 2528070
- DOI: http://doi.org/10.12729/jbtr.2021.22.3.141
Abstract
- A 19-year-old male Siberian tiger was presented with inappetence and paralysis of hind limbs. In a computed tomography (CT) scan, intervertebral disk disease at L3–L4 was detected. Cardiac arrest occurred during the surgery. At autopsy, myxomatous mitral valve degeneration (MMVD) and eccentric hypertrophy of the left heart were noted. The diagnosis was congestive heart failure caused by MMVD. Microscopically, myocardial and pulmonary fibrosis were observed in addition to the disintegration of the fibrosa layer and accumulation of glycosaminoglycans and proteoglycans in the spongiosa layer of the mitral valve. This is the first case of congestive heart failure with MMVD in a Siberian tiger.
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