Osong Public Health Res Perspect.
2022 Feb;13(1):15-23. 10.24171/j.phrp.2021.0293.
Worldwide prevalence of fungal coinfections among COVID-19 patients: a comprehensive systematic review and meta-analysis
- Soltani S
1,2 - Zandi M1,2
- Faramarzi S3
- Shahbahrami R2
- Vali M4
- Rezayat SA5
- Pakzad R6,7
- Malekifar P8
- Pakzad I9
- Jahandoost N10
- Moludi J11
- Affiliations
-
- 1Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
- 2Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
- 3Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
- 4Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
- 5Department of Management & Health Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
- 6Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran
- 7Health and Environment Research Center, Ilam University of Medical Sciences, Ilam, Iran
- 8Department of Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
- 9Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
- 10Department of Microbiology, Faculty of Science, Islamic Azad University, Sanandaj, Iran
- 11School of Nutrition Sciences & Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
- KMID: 2527979
- DOI: http://doi.org/10.24171/j.phrp.2021.0293
Abstract
- Microbial coinfections can increase the morbidity and mortality rates of viral respiratory diseases. Therefore, this study aimed to determine the pooled prevalence of fungal coinfections in coronavirus disease 2019 (COVID-19) patients. Web of Science, Medline, Scopus, and Embase were searched without language restrictions to identify the related research on COVID-19 patients with fungal coinfections from December 1, 2019, to December 30, 2020. A random-effects model was used for analysis. The sample size included 2,246 patients from 8 studies. The pooled prevalence of fungal coinfections was 12.60%. The frequency of fungal subtype coinfections was 3.71% for Aspergillus, 2.39% for Candida, and 0.39% for other. The World Health Organization’s Regional Office for Europe and Regional Office for Southeast Asia had the highest (23.28%) and lowest (4.53%) estimated prevalence of fungal coinfection, respectively. Our findings showed a high prevalence of fungal coinfections in COVID-19 cases, which is a likely contributor to mortality in COVID-19 patients. Early identification of fungal pathogens in the laboratory for COVID-19 patients can lead to timely treatment and prevention of further damage by this hidden infection.
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