Lab Anim Res.
2022 Mar;38(1):57-60. 10.1186/s42826-022-00115-6.
Diagnosis and treatment of macrocytic anemia in a perinatal common marmoset: a case report
- Affiliations
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- 1Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea
- 2Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
- 3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
- 4Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 110-799, Korea
- 5Graduate School of Translational Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Korea
- 6Biomedical Center for Animal Resource and Development, Seoul National University College of Medicine, Seoul, Korea
- 7Designed Animal and Transplantation Research Institute, Institute of Green Bio Science Technology, Seoul National University, Pyeongchang-gun, Gangwon-do, Korea
- KMID: 2527824
- DOI: http://doi.org/10.1186/s42826-022-00115-6
Abstract
- Background
The common marmoset is widely used in current biomedical research for various research fields. We observed macrocytic anemia in a perinatal common marmoset with gradual weight loss and diarrhea. The objective of this case report is to describe the diagnosis and treatment of macrocytic anemia in a perinatal common marmoset.
Case presentation
A 7-year-old female common marmoset showed clinical signs of gradual weight loss and intermittent diarrhea beginning 3 months after giving birth. Macrocytic anemia was diagnosed due to a decreased red blood cell (RBC) count, low hemoglobin level, and increased mean corpuscular volume (MCV). Multivitamins containing cobalamin and folate were administered for 7 days, and the patient’s RBC count recovered to near the normal range with this treatment.
Conclusions
Macrocytic anemia can be diagnosed by evaluating the MCV on a complete blood count (CBC) and cobalamin or folate levels and be treated by supplementation with cobalamin and folate. Such supplements may be needed during pregnancy and lactation in female common marmosets and/or in animals with chronic diarrhea.
