Lab Anim Res.
2022 Mar;38(1):53-56. 10.1186/s42826-022-00114-7.
Pulmonary vein aneurysm in a New Zealand White rabbit: a case report
- Affiliations
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- 1Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 110-799, Korea
- 2Department of Pathology, Chungbuk National University College of Medicine, Cheongju 361-763, Korea
- 3Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea
- 4Graduate School of Translational Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Korea
- 5Biomedical Center for Animal Resource and Development, Seoul National University, College of Medicine, Seoul, Korea
- 6Designed Animal and Transplantation Research Institute, Institute of Green Bio Science Technology, Seoul National University, Pyeongchang-gun, Gangwon-do, Korea
- KMID: 2527823
- DOI: http://doi.org/10.1186/s42826-022-00114-7
Abstract
- Background
Pulmonary venous aneurysm (PVA) is a rare condition characterized by aneurysmal dilatation of the pulmonary vein in humans. The diagnosis is incidental usually as there are no clinical symptoms. This case report describes a histological diagnosis of PVA in a New Zealand White rabbit.
Case presentation
A 1.5-kg male New Zealand White rabbit was acclimatized in an animal room for 5 weeks until the experiment began. However, the rabbit was found dead, with signs of nasal hemorrhage. Necropsy revealed tracheal and pulmonary hemorrhage, and the epistaxis had a pulmonary origin. PCR and ELISA to detect antigens and antibodies pertaining to the rabbit hemorrhagic disease virus showed negative results. Multiple ballooning lesions (50–200 μm size) in the pulmonary veins were observed on histological examination, and PVA was diagnosed. Death was attributed to a spontaneous rupture of the PVA and massive hemorrhage into the lung parenchyma that extended into the trachea and nasal passages.
Conclusions
To the author’s best knowledge, this is the first report of a PVA in a rabbit.
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