Perinatology.  2022 Mar;33(1):21-26. 10.14734/PN.2022.33.1.21.

Clinical Usefulness of Regional Tissue Oxygen Saturation Monitoring Using NearInfrared Spectroscopy in Neonates

• Lee SH
• Yoon SJ
• Lim JH
• Han JH
• Shin JE
• Lee SM
• Eun HS
• Park MS

• KMID: 2527753
• DOI: http://doi.org/10.14734/PN.2022.33.1.21

Abstract

Objective
Recently, near-infrared spectroscopy (NIRS) has been introduced in the neonatal inten sive care unit (NICU) to monitor the altered hemodynamic status causing cerebral hypoxemia or affecting mesenteric and/or renal oxygenation. This study aimed to reassess the clinical usefulness of NIRS and the correlation between regional O₂ saturation (rSO₂ ) and various physiological parameters in neonates.
Methods
Thirty-nine newborns, admitted in NICU from June 2019 to June 2020 and continuously monitored with NIRS (cerebral and renal) during the first 72 hours, were included.
Results
Among 39 newborns with a median gestational age of 33.9 weeks, and a median birth weight of 2,180 g, the median of the cerebral and renal rSO₂ were 84% (30%–95%) and 95% (45%– 95%), respectively. Cerebral rSO₂ tended to increase over time since the time of delivery, while renal rSO₂ tended to decline, especially in preterm infants. Average of renal rSO₂ during 72 hours showed a statistically significant difference between term and preterm infants (P<0.05). Cerebral rSO₂ showed significant correlation with hemoglobin (r=0.35, P<0.05) and hematocrit (r=0.37, P<0.05). Renal rSO₂ showed significant correlation with capillary blood gas analysis such as pH (r=0.36, P<0.05), pCO₂ (r=-0.19, P<0.05), pO₂ (r=0.23, P<0.05), base excess (r=0.19, P<0.05), hemoglobin (r=0.33, P<0.05), hematocrit (r=0.32, P<0.05) as well as renal function indicator such as blood urea nitrogen (r=-0.50, P<0.05) and creatinine (r=-0.59, P<0.05).
Conclusion
We re-evaluated the clinical usefulness of NIRS in neonates by identifying trends and correlations of rSO₂ with clinical parameters. It is necessary to confirm its effectiveness through further study.

Keyword

Spectroscopy; Near-Infrared; Oxygen saturation; Newborn