Anat Cell Biol.  2022 Mar;55(1):109-112. 10.5115/acb.21.164.

Interthalamic adhesion in humans: a gray commissure?

• Parra JED
• Ripoll
• García JFV

• KMID: 2527675
• DOI: http://doi.org/10.5115/acb.21.164

Abstract

Interthalamic adhesion is an inconstant part of the human diencephalic neuroanatomy, which some histological studies have indicated it is a gray commissure and others a white commissure. Its presence has been associated with alterations in health status, including schizophrenia, psychotic states, and hydrocephalus. Thirty-one fresh human brains were evaluated randomly, to determine the presence of interthalamic adhesion and its histological composition, by way of lamina terminalis puncture of the third ventricle. Photographic records were taken and histological processes was performed by hematoxylin-eosin staining, in the case of the existence of the adhesion. It was found that 51.71% did present interthalamic adhesion, and on histological examination, no neuron bodies were found in the median part, which implies that does not correspond to a gray commissure, but interthalamic adhesion in humans is variable, with a predominance of glial cells. There is no gray commissure in human interthalamic adhesions.

Keyword

Anatomy; Diencephalon; Histology; Neuroanatomy; Thalamus

Figure

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  Fig. 1 Medial view of a median section of an encephalon (diencephalon), with a great interthalamic adhesion (black triangles) inferior to the choroid plexus of the third ventricle.

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  Fig. 2 Histological view of a horizontal section of the interthalamic adhesion (zoom ×4) between right and left thalamus in hematoxylin and eosin stain.

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  Fig. 3 Histological view of a horizontal section of the interthalamic adhesion (zoom ×20), in which the absence of gray commissure it is notable, but glial cells are distinguished (black triangles), and laterally, soma of pyramidal neurons (white triangles), with anterior to posterior soma orientation in hematoxylin and eosin stain.

Reference

References

1. Federative Committee on Anatomical Terminology. 1998. Terminologia anatomica: international anatomical terminology. Thieme;New York: p. 120.

2. Lansdell H, Davie JC. 1972; Massa intermedia: possible relation to intelligence. Neuropsychologia. 10:207–10. DOI: 10.1016/0028-3932(72)90061-9.

3. Malobabić S, Puskas L, Blagotić M. 1987; Size and position of the human adhaesio interthalamica. Gegenbaurs Morphol Jahrb. 133:175–80.

4. Trzesniak C, Kempton MJ, Busatto GF, de Oliveira IR, Galvão-de Almeida A, Kambeitz J, Ferrari MC, Filho AS, Chagas MH, Zuardi AW, Hallak JE, McGuire PK, Crippa JA. 2011; Adhesio interthalamica alterations in schizophrenia spectrum disorders: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 35:877–86. DOI: 10.1016/j.pnpbp.2010.12.024. PMID: 21300129.

5. Tubbs RS, Smyth MD, Oakes WJ, Blount JP. 2004; Duplication of the massa intermedia in a child. Pediatr Neurosurg. 40:42–3. DOI: 10.1159/000076578. PMID: 15007230.

6. Vélez García JF, Pedraza Ordoñez FJ, Duque Parra JE. 2013; La adhesión intertalámica del bovino: un estudio piloto. Rev Med Risaralda. 19:30–1. Spanish.

7. Duque A, Roa E, Castedo J. 2008; White matter anatomy using tensor diffusion tractography. Radiologia. 50:99–111. Spanish. DOI: 10.1016/S0033-8338(08)71944-1.

8. Satheesha Nayak B, Soumya KV. 2010; Unusually large interthalamic adhesion and its clinical importance. Int J Anat Var. 3:174–5.

9. Gibbons A. 1991; The brain as "sexual organ". Science. 253:957–9. DOI: 10.1126/science.1887226. PMID: 1887226.

10. Zawitsch C. 1952; Kommissuren und andere Fasersysteme in einer Massa intermedia Thalami des Menschen. Wien Z Nervenheilkd Grenzgeb. 4:74–93. German.

11. Whitehead MT. 2015; Thalamic massa intermedia duplication in a dysmorphic 14 month-old toddler. J Radiol Case Rep. 9:1–5. DOI: 10.3941/jrcr.v9i6.2297. PMID: 26622932. PMCID: PMC4638374.

12. Firbas W, Volavsek C. 1970; Ontogenesis of adhaesio interthalamica (massa intermedia) in man. Anat Anz. 126:205–10. German.

13. Cholvin T, Loureiro M, Cassel R, Cosquer B, Geiger K, De Sa Nogueira D, Raingard H, Robelin L, Kelche C, Pereira de Vasconcelos A, Cassel JC. 2013; The ventral midline thalamus contributes to strategy shifting in a memory task requiring both prefrontal cortical and hippocampal functions. J Neurosci. 33:8772–83. DOI: 10.1523/JNEUROSCI.0771-13.2013. PMID: 23678120. PMCID: PMC6618831.

14. Damle NR, Ikuta T, John M, Peters BD, DeRosse P, Malhotra AK, Szeszko PR. 2017; Relationship among interthalamic adhesion size, thalamic anatomy and neuropsychological functions in healthy volunteers. Brain Struct Funct. 222:2183–92. DOI: 10.1007/s00429-016-1334-6. PMID: 27866270. PMCID: PMC5816973.

15. Olry R, Haines DE. 2005; Interthalamic adhesion: scruples about calling a spade a spade? J Hist Neurosci. 14:116–8. DOI: 10.1080/096470490910128. PMID: 16019656.

16. Kochanski RB, Dawe R, Kocak M, Sani S. 2018; Identification of stria medullaris fibers in the massa intermedia using diffusion tensor imaging. World Neurosurg. 112:e497–504. DOI: 10.1016/j.wneu.2018.01.066. PMID: 29408589.

17. Rabl R. 1958; Studies on the structure of the massa intermedia of the thalamus opticus. J Hirnforsch. 4:78–112. German. DOI: 10.1515/9783112532669-005. PMID: 13598875.

18. Ciftcioglu E, Ozyurek H, Nural MS, Kopuz C, Incesu L, Ogur G. 2015; Absence of the lateral and third ventricles associated with holoprosencephaly. Anat Cell Biol. 48:222–4. DOI: 10.5115/acb.2015.48.3.222. PMID: 26417484. PMCID: PMC4582167.

19. Duque Parra JE, Marín Arias F, Duque Vera IL. Interthalamic adhesion: an approach from basic science to implement clinic neuroimaging. Paper presented at: 3rd European Conference on Clinical Neuroimaging. 2014 Mar 31-Apr 1; Lille, France. p. 27–8.

20. Mohammadi MR, Hosseini SH, Golalipour MJ. 2008; Morphometric measurements of the thalamus and interthalamic adhesion by MRI in the South-East of the Caspian Sea border. Neurosciences (Riyadh). 13:272–5.

21. Laslo P, Slobodan M, Nela P, Milos M, Rade P, Tatjana I. 2005; Specific circular organization of the neurons of human interthalamic adhesion and of periventricular thalamic region. Int J Neurosci. 115:669–79. DOI: 10.1080/00207450590524340. PMID: 15823931.

22. Agarwal N, Rambaldelli G, Perlini C, Dusi N, Kitis O, Bellani M, Cerini R, Isola M, Versace A, Balestrieri M, Gasparini A, Mucelli RP, Tansella M, Brambilla P. 2008; Microstructural thalamic changes in schizophrenia: a combined anatomic and diffusion weighted magnetic resonance imaging study. J Psychiatry Neurosci. 33:440–8.

23. Haghir H, Mokhber N, Azarpazhooh MR, Haghighi MB, Radmard M. 2013; A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia. Indian J Psychiatry. 55:135–9. DOI: 10.4103/0019-5545.111450. PMID: 23825846. PMCID: PMC3696235.

24. de Souza Crippa JA, Zuardi AW, Busatto GF, Sanches RF, Santos AC, Araújo D, Amaro E, Hallak JE, Ng V, McGuire PK. 2006; Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. Eur Psychiatry. 21:291–9. DOI: 10.1016/j.eurpsy.2005.09.010. PMID: 16406503.

25. Takahashi T, Yücel M, Yung AR, Wood SJ, Phillips LJ, Berger GE, Ang A, Soulsby B, McGorry PD, Suzuki M, Velakoulis D, Pantelis C. 2008; Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders. Prog Neuropsychopharmacol Biol Psychiatry. 32:1708–14. DOI: 10.1016/j.pnpbp.2008.07.007. PMID: 18675876.

26. Cheng S, Tan K, Bilston LE. 2010; The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles. J Biomech. 43:579–82. DOI: 10.1016/j.jbiomech.2009.10.002. PMID: 19896132.

27. Samra KA, Cooper IS. 1968; Radiology of the massa intermedia. Radiology. 91:1124–8. DOI: 10.1148/91.6.1124. PMID: 5303380.

28. Dauber W, Feneis H. 2007. Pocket atlas of human anatomy. 5th ed. Thieme;New York: p. 360. DOI: 10.1055/b-005-148848.

29. Park KA, Lee HY, Chung IH, Han YP, Shin TS. 1993; A morphologic study of interthalamic adhesions in Korean brains. Clin Anat. 6:33–6. DOI: 10.1002/ca.980060106.

30. Sullivan EV, Rosenbloom M, Serventi KL, Pfefferbaum A. 2004; Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging. 25:185–92. DOI: 10.1016/S0197-4580(03)00044-7.

31. Paulus W. 2016; Los efectos de la estimulación transcraneal. Mente Cereb. 76:46–53. Spanish.