J Korean Med Assoc.  2022 Mar;65(3):167-172. 10.5124/jkma.2022.65.3.167.

Development of a graphical model of causal gene regulatory networks using medical big data and Bayesian machine learning

• Park SB
• Yoo C

• KMID: 2527357
• DOI: http://doi.org/10.5124/jkma.2022.65.3.167

Abstract

Background
Data collection from medicine and biomedical science is becoming a large task and increasingly complicated with each passing day. Machine learning methods have been applied to elucidate interactions between genes and genes and their environment.
Current Concepts
Many machine learning methods have been used to determine the statistical meaning or relationship in the prediction or progression of diseases through the creation of causal networks based on medical big data. Through these analyses, the occurrence and progression of diseases have been shown to be related to several genes and environmental factors. However, these methods cannot identify the key upstream regulators inferred from genomic, clinical, and environmental medical data.
Discussion and Conclusion
The causal Bayesian network (CBN) is a machine learning method that can be used to understand a causal network inferred from the gene expression data. The CBN can help identify the key upstream regulators through examining the causal network inferred from medical big data having genomic information. We can easily improve the clinical outcome through regulation of these identified key upstream factors. Therefore, the CBN may be a powerful and flexible tool in the era of precision medicine.

Keyword

Bayesian analysis; Big data; Gene regulatory network; 베이시안분석; 빅데이터; 유전자조절네트워크