Lab Med Online.  2021 Jul;11(3):211-213. 10.47429/lmo.2021.11.3.211.

A Case of Therapy-related Acute Promyelocytic Leukemia Lacking t(15;17) on Karyotype

• Lee J
• Kim YE

• KMID: 2526075
• DOI: http://doi.org/10.47429/lmo.2021.11.3.211

Figure

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  Fig. 1 (A) Granular promyelocytes from bone marrow aspiration smear (Wright-Giemsa stain, ×1,000). (B) Giemsa-banding karyotyping of the bone marrow cells at diagnosis reveals the karyotype 46,XX. (C) Fluorescence in situ hybridization (FISH) study using a PML/RARA dual-color, dual-fusion translocation probe at diagnosis. Fusion signals were observed. (D) RT-PCR for PML/RARA fusion transcripts. S-form (325 bp) PML/RARA chimeric transcripts were amplified. Abbreviation: RT-PCR, reverse-transcriptase polymerase chain reaction.

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