J Korean Soc Radiol.
2022 Jan;83(1):246-251. 10.3348/jksr.2021.0045.
Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
- Affiliations
-
- 1Department of Radiology, Ewha Womans University Mokdong Hospital, Seoul, Korea
- KMID: 2525195
- DOI: http://doi.org/10.3348/jksr.2021.0045
Abstract
- Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Late-Onset Li-Fraumeni-like Syndrome with Unilateral Breast Cancer
- The first documentation of Li-Fraumeni syndrome in Korea
- Genetic Counseling Can Influence the Course of a Suspected Familial Cancer Syndrome Patient: From a Case of Li-Fraumeni Like Syndrome with a Germline Mutation in the TP53 Gene
- Family of Li-Fraumeni Syndrome with a Germline Mutation in the p53 Gene
- Osteosarcoma with Adenocarcinoma of Lung in Li-Fraumeni Syndrome: A Case Report
