J Obes Metab Syndr.  2021 Dec;30(4):396-402. 10.7570/jomes21040.

One-Anastomosis and Roux-en-Y Gastric Bypass Promote Similar Weight Loss, Patient Satisfaction, Quality of Life, Inflammation Grade, and Cellular Damage in the Esophagus and Gastric Pouch in a Short-term Follow-up

• Katayama RC
• Arasaki CH
• Herbella FA
• Neto RA
• Filho GdJL

• KMID: 2524579
• DOI: http://doi.org/10.7570/jomes21040

Abstract

Background
One-anastomosis gastric bypass (OAGB) is a simpler procedure than Roux-en-Y gastric bypass (RYGB); however, biliary reflux can occur and impair outcomes. This study aimed to compare outcomes of OAGB and RYGB.
Methods
Twenty patients with morbid obesity were randomized prospectively into two groups: OAGB (n= 10) or RYGB (n= 10). Quality of life (36-item short-form health survey [SF-36]), satisfaction (Visick scale), and body mass index (BMI) were evaluated before and 6 months after the operation. All patients underwent esophagogastroduodenoscopy with gastric and esophageal mucosal biopsies at 3 and 6 months after their operation.
Results
The study found no significant difference in BMI before surgery (OAGB, 43.2 kg/m² ; RYGB, 43.1 kg/m² ; P= 0.90) or at 6 months postoperative (OAGB, 32.1 kg/m² ; RYGB, 31.8 kg/m² ; P= 0.91). There was no significant difference in improvement of quality of life (four SF-36 domains) or satisfaction (P= 0.08) between groups at 6 months. There was no statistical difference between gastric (P= 0.10) and esophageal (P= 0.76) inflammation grade at three or 6 months between the two groups.
Conclusion
OAGB and RYGB are equally effective in terms of weight loss, patient satisfaction, and quality of life improvement at 6 months after the procedures. Inflammation grade and cellular damage in the gastric pouch and in the esophagus were similar.

Keyword

One-anastomosis gastric bypass; Roux-en-Y gastric bypass; Biliary reflux; Morbid obesity; Quality of life, Weight loss