Nucl Med Mol Imaging.  2021 Dec;55(6):320-322. 10.1007/s13139-021-00724-4.

Incidental Muscle Uptake of  ¹⁷⁷ Lu-DOTATATE in Peripheral Vascular Disease

• Aggarwal P
• Chandekar K
• Sood A
• Zerial S
• Kumar R
• Sinha A

• KMID: 2523588
• DOI: http://doi.org/10.1007/s13139-021-00724-4

Abstract

Somatostatin receptor (SSTR)-based imaging and therapy has emerged as well-established modality in neuroendocrine tumors. However, its role in inflammation imaging is still evolving. We present a 48-year-old male with metastatic neuroendocrine tumor who underwent lutetium-177-based somatostatin receptor-based therapy. The post-therapy scan showed a focal tracer uptake in the left calf muscle in addition to the expected tracer uptake at the primary and metastatic sites. Further, cross-sectional imaging and biochemical investigations revealed peripheral vascular disease (PVD). The incidental tracer uptake in the calf on post-therapy scan potentiates the role of somatostatin receptor scintigraphy in identifying macrophagespecific inflammatory reactions.

Keyword

Lutetium-177; DOTATATE; Neuroendocrine tumors; Peripheral vascular diseases