Osong Public Health Res Perspect.  2021 Oct;12(5):324-332. 10.24171/j.phrp.2021.0207.

Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers

• Kim HR
• Seo CW
• Yoo K
• Han SJ
• Kim J

• KMID: 2523345
• DOI: http://doi.org/10.24171/j.phrp.2021.0207

Abstract

Objectives
The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers.
Methods
The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data.
Results
The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types.
Conclusion
These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.

Keyword

Correlation study; Neoplasms; Prognosis; Telomerase; Telomerase RNA; Yes-associated protein 1