Perinatology.  2021 Sep;32(3):105-110. 10.14734/PN.2021.32.3.105.

Mesenchymal Stem Cell Therapy for Intrac table Neonatal Disorders

• Ahn SY

• KMID: 2522525
• DOI: http://doi.org/10.14734/PN.2021.32.3.105

Abstract

Mesenchymal stem cell (MSC) transplantation has generated great interest as a new promising therapeutic strategy for the next generation therapy of intractable and devastating newborn disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intra ventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In the disease environ ment of active inflammatory and noxious stimuli, MSCs have been believed to excrete multiple secretomes those may play restorative actions, including anti-inflammatory, anti-oxidative, antiapoptotic, and anti-fibrotic actions, to promote the recovery of injury tissue. In this review, recent progress in stem cell research for the treatment of neonatal BPD, IVH and HIE, was introduced with preclinical and clinical data.

Keyword

Infant; Newborn; Mesenchymal stem cells; Mesenchymal stem cell transplantation; Clinical trial