Brain Tumor Res Treat.  2021 Oct;9(2):63-69. 10.14791/btrt.2021.9.e16.

Effect of Cadherin-11 Expression on the Prognosis of a Newly Diagnosed Primary Glioblastoma

• Seo H
• Lee HW
• Yoon SY
• Chang SH
• Park SH
• Hwang JH
• Park TI
• Park KS

• KMID: 2522221
• DOI: http://doi.org/10.14791/btrt.2021.9.e16

Abstract

Background
Cadherin-11, a cell-to-cell adhesion molecule, is associated with higher tumor grade and decreased patient survival. The purpose of this study was to investigate the clinical significance of cadherin-11 expression in the progression and prognosis of a newly diagnosed primary glioblastoma (GBL).
Methods
Between 2007 and 2016, 52 out of 178 patients diagnosed with a GBL and satisfied the following criteria: 1) a new primary GBL, 2) gross-total resection, 3) immunohistochemically-available tissue, and 4) standardized adjuvant treatment.
Results
In terms of staining intensity, the low-intensity cadherin-11 group showed longer progression-free survival (PFS) than the high-intensity cadherin-11 group (median PFS, 12.0 months [95% CI, 11.1-12.9] vs. median PFS, 6.0 months [95% CI, 3.7-8.3]; p<0.001). The low-intensity cadherin-11 group revealed longer overall survival (OS) than the high-intensity cadherin-11 group (median OS, 20.0 months [95% CI, 11.8-16.6] vs. median OS, 15.0 months [95% CI, 11.8-18.2]; p=0.003). The staining intensity of cadherin-11 was a statistically significant factor in PFS and OS in terms of univariate and multivariate analyses (univariate analysis: p<0.001 and p=0.005; multivariate analysis: p<0.001 and p=0.005).
Conclusion
Our clinical study demonstrates high cadherin-11 expression may be associated with poor PFS and OS for a newly diagnosed primary GBL.

Keyword

Glioblastoma; Cadherins; Overall; Survival; Progression-free survival

Figure

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  Fig. 1 Cadherin-11 immunohistochemical staining (original magnification ×200; scale bar=100 µm). A: Negative staining of tumor cells. B: Less staining intensity than endothelial cells (arrow). C: Similar staining intensity to endothelial cells (arrow). D: Greater staining intensity than endothelial cells (arrow).

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  Fig. 2 The PFS (A) and OS (B) plots according to the staining intensity of cadherin-11.PFS, progression-free survival; OS, overall survival.

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