Ann Dermatol.
2021 Dec;33(6):577-581. 10.5021/ad.2021.33.6.577.
Neonatal Generalized Lymphatic Anomaly with Skin Involvement
- Affiliations
-
- 1Departments of Neonatology, Mother and Child Health Care Institute of Serbia, Belgrade, Serbia, Spain
- 2Departments of Clinical Pathology, Mother and Child Health Care Institute of Serbia, Belgrade, Serbia, Spain
- 3Dapartment of Pathology, School of Medicine, University of Banjaluka, Banjaluka, Bosnia and Herzegovina, Spain
- 4Department of Pulmonology, Mother and Child Health Care Institute of Serbia, Spain
- 5Department of Pediatrics, School of Medicine, University of Belgrade, Belgrade, Serbia, Spain
- 6Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
- KMID: 2522138
- DOI: http://doi.org/10.5021/ad.2021.33.6.577
Abstract
- Generalized lymphatic anomaly (GLA) is a rare congenital disorder of lymphatic development, presenting with multiple lymphatic malformations in different organs and tissues. Here, we present a case of a female neonate prenatally diagnosed with foetal hydrops and a mediastinal cystic lymphatic malformation that showed postnatal expansive and infiltrative growth into the major airways, compromising mechanical ventilation and further management of the neonate. Complications that arose during surgical treatment of mediastinal structures led to the patient’s death. Lymphatic malformations were also noted in the skin at birth. Furthermore, a skin biopsy performed immediately after birth and the autopsy revealed an extremely rare diagnosis of combined macrocystic and microcystic forms of GLA with skin involvement.
