Anxiety Mood.  2021 Oct;17(2):84-91. 10.24986/anxmod.2021.17.2.006.

Comparison of Mismatch Negativity According to Suicidal Ideation in Patients With Major Depressive Disorder

• Lee M
• Lee YJ
• Hwang J
• Woo Si
• Kim MJ
• Kang B
• Kim Y
• Hahn SW

• KMID: 2522105
• DOI: http://doi.org/10.24986/anxmod.2021.17.2.006

Abstract

Objective
: Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive function-ing. This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients with or without suicidal ideation.
Methods
: Sixty-seven patients with MDD were recruited into this study. MMN was measured by a 64-channel electroencephalography (EEG) using oddball paradigm over the front-central area. Clinical char-acteristics were assessed using the Beck Anxiety Inventory (BAI), the Beck Depression Inventory-II (BDI-II), and the Beck Scale for Suicide ideation (SSI-BECK). Patients were divided into two groups, no suicidal ideation (N=12) and suicidal ideation (N=55), depending on the presence of suicide ideation in SSI-BECK questionnaires.
Results
: The MMN latencies were significantly longer in the MDD patients with suicidal ideation than in the MDD patents without suicidal ideation (p<0.05). The MMN amplitudes were not significantly differ-ent between the two groups.
Conclusion
: Suicidal ideation may be associated with longer MMN latencies, and it suggests that MMN may play a potential role in assessing the suicidal risk among MDD patients.

Keyword

Mismatch negativity; Suicidal ideation; Major depressive disorder.