Korean J Fam Pract.  2021 Oct;11(5):372-378. 10.21215/kjfp.2021.11.5.372.

Correlation between Gastroscopy Findings and Pepsinogen Values

• Yoon DI
• Choi M
• Yoon YJ
• Lee HK
• Cho SJ
• Kim WJ
• Kim JH

• KMID: 2521442
• DOI: http://doi.org/10.21215/kjfp.2021.11.5.372

Abstract

Background
If the pepsinogen (PG) level could indicate the condition of the gastric mucosa, it can rapidly diagnose atrophic gastritis, a high risk factor for stomach cancer. Based on varying distribution and location of secreted cells of PG I and PG II, this study aimed to determine the correlation between gastroscopy findings and PG levels.
Methods
From January to December 2018, gastroscopy findings in 103 subjects were compared according to PG I, PG II, and PG I/II ratio, with adjustments for sex, age, body mass index, underlying diseases, family history of stomach cancer, and social history.
Results
The group with atrophic gastritis had a significantly higher PG II value and a significantly lower PG I/II ratio than the control group. Those with a higher Los Angeles classification of reflux esophagitis were observed to have higher PG I and II levels, although this finding was not statistically significant. In cases of heartburn, duodenitis, intestinal metaplasia, and Helicobacter pylori infection, PG I and II levels were low, but not statistically significant.
Conclusion
After adjusting for the characteristics of subjects, a low PG I/II ratio was found to be a useful predictive factor for atrophic gastritis.

Keyword

Pepsinogen; Atrophic Gastritis; Gastroscopy; Screening Test