Korean J Transplant.  2021 Oct;35(Supple 1):S182. 10.4285/ATW2021.OR-1009.

Experimental intestial transplant: a factor of successful introduction in human of Vietnam

• Hai DX
• Quyet D
• Vu NT
• Hoa NT

• KMID: 2521293
• DOI: http://doi.org/10.4285/ATW2021.OR-1009

Abstract

Background
Intestinal transplantation experiments is very important role in intestinal transplantation research. We conducted this study to find a model close to the human intestinal transplant model and observe some post-transplant results.
Methods
Including five pigs and five dogs to study the anatomy of the small intestine. Including eight pigs and 10 dogs to perform intestinal transplantation models and evaluate the results. The status of anastomosis, the condition of the intestines (12th hour) on a scale of 1 to 5: 1+ (good), 2+ (moderate), 3+ (bad), 4+ (necrosis). Outcome of survival and cause of failure.
Results
The anatomy of the small intestine of pigs is similar to that of humans. However, the intestines in dogs have many special differences in the arrangement of intestinal loops and colon. The source is the superior mesenteric artery, which feeds an intestinal length from 10 to 14 m, so it is usually taken from the ligament of Treitz about 2–4 m to ensure good vascularity after transplantation (model 1). The source of the supply is the inferior mesenteric artery, a segment of intestine about 1–2 m can also be taken (model 2). With the dog model, it is possible to create a model of a small intestine (model 3) or almost the entire small intestine (model 4). With the above intestinal transplant models performed. We evaluated at 12 hours post-transplant. With models 2 and 3, it is found that there is a higher success rate than in models 1 and 4. Attention should be paid to the spatial orientation of the small intestine after transplantation and the mesenteric artery pressure.
Conclusions
Performing pairs with many model changes found that pig intestine transplantation is appropriate and these initial successes are the scientific basis for the successful implementation of the first two intestinal transplants in Vietnam.